Dr. Prabhu Nesargikar
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PIPAC Surgery

PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy)

PIPAC, or Pressurized Intraperitoneal Aerosol Chemotherapy, represents a significant advancement in the palliative and therapeutic management of peritoneal surface malignancies. Unlike traditional systemic chemotherapy, PIPAC is a minimally invasive technique that delivers chemotherapy directly into the abdominal cavity in the form of a pressurized aerosol (mist).

PIPAC Procedure

This method is specifically designed for patients with advanced peritoneal carcinomatosis who may not be eligible for major cytoreductive surgery. By using a specialized nebulizer, the chemotherapy is distributed uniformly across the entire abdominal lining, allowing for improved tissue penetration and efficacy with lower systemic toxicity.

How PIPAC Works

During the procedure, which is performed via a simple laparoscopy, a small amount of chemotherapy is converted into a pressurized mist within the closed abdomen. The pressure gradient created during the procedure improves the delivery of the drug into the tumor tissue compared to liquid delivery methods. Because the procedure is minimally invasive, it is generally well-tolerated, allowing patients to undergo repeated treatments at regular intervals to control the disease progression and manage symptoms effectively.

Indications and Advantages

PIPAC is primarily utilized for patients with non-resectable peritoneal metastases from various primary cancers, including gastric, ovarian, and colorectal origins. The key advantages of PIPAC include its ability to treat patients who have failed or are resistant to systemic chemotherapy, the minimal surgical trauma involved, and the potential for improved quality of life through better symptom control—such as the reduction of malignant ascites. It is often a key component of a personalized, long-term oncological management strategy.

Safety and Patient Experience

The safety profile of PIPAC is excellent, with minimal recovery time required. Most patients are discharged shortly after the procedure and can often resume their daily activities within a few days. Our clinic utilizes advanced safety protocols during the delivery of the aerosol to ensure the highest standards of protection for both the patient and the operating room staff. We work closely with our patients to monitor their response to the treatment, tailoring the frequency of the aerosol sessions to meet their specific clinical needs.

Why Dr. Prabhu for PIPAC
20+ Years of Experience
500+ Surgeries
1000+ Happy Patients
Expert PIPAC Specialist

Considering PIPAC?

If you are exploring options for advanced peritoneal disease, we invite you to discuss the role of PIPAC in your treatment plan.

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